Targeted Drug Delivery / Smart Drug Delivery / Drug Targeting
Fariba Ganji; Fateme Hoobakht; Farzane Ghasemi Tahrir; Ebrahim Vasheghani-Farahani
Volume 8, Issue 3 , September 2014, , Pages 249-260
Abstract
Somanis one of the strongest nerve agents and treatment of poisoning with Soman is difficult and time-critical. Pyridostigmine bromide is an inhibitor of cholinesterase used for protecting against toxicity by Soman. In this study, a new injectable thermosensitive sustained release dosage form of pyridostigmine ...
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Somanis one of the strongest nerve agents and treatment of poisoning with Soman is difficult and time-critical. Pyridostigmine bromide is an inhibitor of cholinesterase used for protecting against toxicity by Soman. In this study, a new injectable thermosensitive sustained release dosage form of pyridostigmine bromide was achieved by chitosan/glycerolphosphate solution. In this study, thermosensitivity and rheological properties of chitosan solution (2% w/v) in aqueous hydrochloric acid (0.1 molar) with different percent of glycerolphosphate salt as well as the release profile of pyridostigmine bromide have been investigated. It was observed that increasing the glycerolphosphate salt concentration would increase the pH of chitosan solution, while decrease its gelation time and loss or storage modulus. It was also observed that glycerolphosphate salt concentration has direct effect on hydrogel thermoreversibility. The presented results indicated that hydrogel containing 2% w/v of chitosan and 16% w/v of glycerolphosphate salt could sustain the delivery of pyridostigmine bromide, through Fickian diffusion, up to four days.
